We specialize in the Clinical Application of Neuroscience to maximize intelligence, catalyze creativity and enhance brain plasticity.

Dr. Donalee Markus' cognitive restructuring treatment is featured in The Ghost in My Brain by Clark Elliott, Ph.D., a compelling account of recovery that highlights the transformative power of brain plasticity for those with concussion and brain trauma.

The Research Behind Neuroplasticity

Dr. Markus’s work uses hierarchically organized visual puzzles that move from simple to more advanced challenges. This approach is informed by research showing that repeated practice, sustained attention, and increasing challenge can support learning and neuroplastic change.

Brain plasticity and repeated practice

Neuroplasticity Through Practice

The brain changes through behavior, practice, and experience rather than through a shortcut or passive method.

Learning through challenge and focus

Learning Gets Stronger With Effort

Increased struggle during practice can lead to greater learning and structural change in the brain.

SuperAger memory and aging

SuperAger Brain Resilience

Northwestern’s SuperAger research studies older adults with exceptionally strong memory to learn what supports healthy cognitive aging.

Structured cognitive challenge

Structured Cognitive Challenge

Hierarchical puzzles create a gradual increase in difficulty, which keeps the brain actively engaged and learning at each level.

Informed by Science. Supported by Evidence.

Designs for Strong Minds is connected to a growing body of neuroscience research. The approach draws on brain plasticity science, SuperAger studies, and decades of clinical observation.

Dr. Donalee Markus

Over 40 years of clinical work in cognitive restructuring. Dr. Markus developed a system of context-free exercises that engage the brain's visual processing networks to support learning, memory, and reasoning.

Neuroplasticity Research

The broader neuroscience community has established that the brain continues to reorganize itself by forming new neural connections throughout life — a principle at the core of this work.

SuperAger Science

SuperAger research explores why some people maintain exceptional memory and cognitive function well into old age. This body of work informs the design of the exercises and training approach.

The Ghost in My Brain

Clark Elliott's book documents his experience with cognitive restructuring after a traumatic brain injury — including his work with Dr. Donalee Markus and the exercises that supported his recovery.

Suite of Digital Brain Games

Each app targets a key domain of cognition, with natural overlap that reinforces overall performance — memory tracking, recall speed, visual reasoning, and more. Together, they form a connected suite for lifelong brain training.

Work with Dr. Markus

For those who want personalized guidance, Dr. Donalee Markus offers one-on-one cognitive restructuring consultations.

Personalized cognitive assessment
Custom exercise programs tailored to your needs
Suitable for brain injury recovery, aging, and learning goals
Virtual consultations available

Neuroscience is the
science of HOPE!

Dr. Donalee Markus with Professor Reuven Feuerstein

Dr. Donalee Markus with
The Father of Teachable Intelligence
Professor Reuven Feuerstein

Learn More About Dr. Markus

Real Life Testimonials

Real Life Testimonials

"After playing Strong Mind Mazes for about a week, my brain just clicked. When it happened, it's almost like my subconscious took over the processing. I went from struggling to completing mazes in under a minute."

Thomas Z. Computer scientist — TBI recovery after 8-year plateau

"I will work hard to spread the word of neuroplasticity and how it has helped me. I could feel my brain learning to learn again during the week-long intensive treatment in Chicago."

S.R. College student — refused to accept "new normal" diagnosis

"She helped me think about my thinking and I became more confident. I shifted from giving up to persistence and improved from failing to my best grades ever. I actually don't mind school now and believe I can be successful in college."

Patrick High school athlete, age 16 — struggled with focus and grades

"I am able to converse again, exercise again. My reading, math skills, and time-management skills have returned. I graduated college at 80%+ recovery and now have confidence in my future."

Kiared (Kia) Pashminehazar College graduate, 2022 — three concussions

"Learning alternative ways of perception has re-designed my thinking patterns, alleviated stress, and brought clarity to the big picture. The transformation brought success in both my personal and business life."

Richard Entrepreneur, age 26

Search Our Site

Explore 40+ years of research, tools, and resources from the Designs for Strong Minds library.

What SuperAgers can teach us about the aging brain.

SuperAgers are individuals over 80 whose memory performance rivals people decades younger. Their brains offer clues about what keeps cognition sharp — and how training may play a role.

Ready to start training your brain?